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Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant <i>Mycobacterium tuberculosis</i>

Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MDR or XDR) TB. A greater understanding of host and...

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Principais autores: Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2023-07-01
סדרה:Microorganisms
נושאים:
tuberculosis
multidrug-resistant TB
cathepsins
cystatins
host-directed therapies
גישה מקוונת:https://www.mdpi.com/2076-2607/11/7/1861
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