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NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma

IntroductionImproving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL. Transcriptionally active NF-κB is a dimer containing either RelA, RelB or cRel, but the variabilit...

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Principais autores: Eleanor Jayawant, Arran Pack, Heather Clark, Emma Kennedy, Ankur Ghodke, John Jones, Chris Pepper, Andrea Pepper, Simon Mitchell
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-06-01
coleção:Frontiers in Oncology
Assuntos:
systems biology
DLCBL
NFkB
TME (tumor microenvironment)
math modeling
lymphoma
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2023.1181660/full
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