Persistent activation of monocytes/macrophages and cell senescence in SIV-infected macaques on ART

IntroductionDespite effective viral suppression with antiretroviral therapy (ART), people living with HIV (PLWH) experience persistent inflammation, immune dysfunction, and premature onset of cardiovascular and aging-related comorbidities. The mechanisms driving this transition from acute immune act...

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Principais autores:	Yilin Chen, Xiaofeng Ding, Sonalika Ray, Siva Thirugnanam, Robert V. Blair, Ahmad Saied, Sergiy Sukhanov, Jay K. Kolls, Woong-Ki Kim, Patrice Delafontaine, Jay Rappaport, Xuebin Qin, Namita Rout
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Immunology
Assuntos:	ART caspase-1 IL27 inflammaging macrophage NFkB
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1788994/full
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