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Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4

Abstract Prokaryotic defense-associated reverse transcriptase (DRT) systems confer host resistance to viral infection through DNA synthesis; however, the molecular mechanisms underlying their function remain poorly understood. Here, we demonstrate that DRT4, a single-gene anti-phage defense system,...

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Autors principals: Yong Wang, Hao Wu, Jinyue Li, Qiyin An, Zhenhua Tian, Zengqin Deng
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-12-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-025-66997-x
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