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Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization

Abstract Neuronal communication relies on precisely maintained synaptic vesicle (SV) clusters, which assemble via liquid-liquid phase separation. This process requires synapsins, the major synaptic phosphoproteins, which are known to bind actin. Reorganization of SVs, synapsins, and actin is a hallm...

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Автори: Akshita Chhabra, Christian Hoffmann, Gerard Aguilar Pérez, Aleksandr A Korobeinikov, Jakob Rentsch, Nadja Hümpfer, Linda Kokwaro, Luka Gnidovec, Arsen Petrović, Jaqulin N Wallace, Johannes Vincent Tromm, Cristina Román-Vendrell, Emma C Johnson, Branislava Ranković, Eleonora Perego, Tommaso Volpi, Rubén Fernández-Busnadiego, Sarah Köster, Silvio O Rizzoli, Helge Ewers, Jennifer R Morgan, Dragomir Milovanović
Формат: Artigo
Мова:Inglês
Опубліковано: Springer Nature 2025-08-01
Серія:The EMBO Journal
Предмети:
Actin
Synapsin
Presynapses
Synaptic Vesicles
Liquid-Liquid Phase Separation
Онлайн доступ:https://doi.org/10.1038/s44318-025-00516-y
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