Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization

Abstract Neuronal communication relies on precisely maintained synaptic vesicle (SV) clusters, which assemble via liquid-liquid phase separation. This process requires synapsins, the major synaptic phosphoproteins, which are known to bind actin. Reorganization of SVs, synapsins, and actin is a hallm...

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Autori principali:	Akshita Chhabra, Christian Hoffmann, Gerard Aguilar Pérez, Aleksandr A Korobeinikov, Jakob Rentsch, Nadja Hümpfer, Linda Kokwaro, Luka Gnidovec, Arsen Petrović, Jaqulin N Wallace, Johannes Vincent Tromm, Cristina Román-Vendrell, Emma C Johnson, Branislava Ranković, Eleonora Perego, Tommaso Volpi, Rubén Fernández-Busnadiego, Sarah Köster, Silvio O Rizzoli, Helge Ewers, Jennifer R Morgan, Dragomir Milovanović
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2025-08-01
Serie:	The EMBO Journal
Soggetti:	Actin Synapsin Presynapses Synaptic Vesicles Liquid-Liquid Phase Separation
Accesso online:	https://doi.org/10.1038/s44318-025-00516-y
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