SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and migration. We found that SHARPIN localizes to the trailing edges (uropods) of both mouse and human...

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Autors principals:	Jeroen Pouwels, Nicola De Franceschi, Pia Rantakari, Kaisa Auvinen, Marika Karikoski, Elina Mattila, Christopher Potter, John P. Sundberg, Nancy Hogg, Carl G. Gahmberg, Marko Salmi, Johanna Ivaska
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2013-11-01
Col·lecció:	Cell Reports
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124713005809
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