Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro

Abstract Background Glioblastoma multiforme (GBM) is an aggressive tumor, difficult to treat pharmacologically because of the blood-brain barrier (BBB), which is rich in ATP-binding cassette (ABC) transporters and tight junction (TJ) proteins. The BBB is disrupted within GBM bulk, but it is competen...

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Autori principali:	Sabrina Digiovanni, Martina Lorenzati, Olga Teresa Bianciotto, Martina Godel, Simona Fontana, Muhlis Akman, Costanzo Costamagna, Pierre-Olivier Couraud, Annalisa Buffo, Joanna Kopecka, Chiara Riganti, Iris Chiara Salaroglio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-11-01
Serie:	Fluids and Barriers of the CNS
Soggetti:	Blood-brain barrier Glioblastoma multiforme Glioblastoma stem cells ATP Binding Cassette transporters Tight junctions Interleukin-6
Accesso online:	https://doi.org/10.1186/s12987-024-00590-0
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