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Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5

IntroductionThe mechanism underlying radiation-induced gut microbiota dysbiosis is undefined. This study examined the effect of radiation on the intestinal Paneth cell α-defensin expression and its impact on microbiota composition and mucosal tissue injury and evaluated the radio-mitigative effect o...

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Principais autores: Pradeep K. Shukla, Roshan G. Rao, Avtar S. Meena, Francesco Giorgianni, Sue Chin Lee, Preeti Raju, Nitesh Shashikanth, Chandra Shekhar, Sarka Beranova, Louisa Balazs, Gabor Tigyi, Ankush Gosain, RadhaKrishna Rao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-08-01
Colecção:Frontiers in Immunology
Assuntos:
GI-ARS
irradiation
defensins
tight junction
intestine
barrier function
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174140/full
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