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Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5

IntroductionThe mechanism underlying radiation-induced gut microbiota dysbiosis is undefined. This study examined the effect of radiation on the intestinal Paneth cell α-defensin expression and its impact on microbiota composition and mucosal tissue injury and evaluated the radio-mitigative effect o...

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Principais autores: Pradeep K. Shukla, Roshan G. Rao, Avtar S. Meena, Francesco Giorgianni, Sue Chin Lee, Preeti Raju, Nitesh Shashikanth, Chandra Shekhar, Sarka Beranova, Louisa Balazs, Gabor Tigyi, Ankush Gosain, RadhaKrishna Rao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-08-01
Serier:Frontiers in Immunology
Fag:
GI-ARS
irradiation
defensins
tight junction
intestine
barrier function
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174140/full
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