Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists
We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors. Molecular docking of all investigated compounds revealed subnanomolar estimates of 5-HT<sub>1A</sub>R...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2021-02-01
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| coleção: | Pharmaceuticals |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1424-8247/14/3/179 |
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