Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties

Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed to obtain an affinity profile at serotonin 5-H...

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Библиографические подробности

Главные авторы:	Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-02-01
Серии:	Molecules
Предметы:	serotonin dopamine 5-HT<sub>1A</sub> 5-HT<sub>2A</sub> 5-HT<sub>7</sub> D<sub>2</sub>
Online-ссылка:	https://www.mdpi.com/1420-3049/27/4/1297
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