A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes

Metformin has been demonstrated to attenuate hyperglycaemia by modulating the gut microbiota. However, the mechanisms through which the microbiome mediates metformin monotherapy failure (MMF) are unclear. Herein, in a prospective clinical cohort study of newly diagnosed type 2 diabetes mellitus (T2D...

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Главные авторы:	Manyun Chen, Yilei Peng, Yuhui Hu, Zhiqiang Kang, Ting Chen, Yulong Zhang, Xiaoping Chen, Qing Li, Zuyi Yuan, Yue Wu, Heng Xu, Gan Zhou, Tao Liu, Honghao Zhou, Chunsu Yuan, Weihua Huang, Wei Zhang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-05-01
Серии:	Acta Pharmaceutica Sinica B
Предметы:	Metformin resistance Ceramide Mitochondrial dysfunction Oxidative phosphorylation Gut microbiota Farnesoid X receptor
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2211383525000516
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