Intranasal delivery of mesenchymal stem cell‐derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Abstract The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal stem c...

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Автори:	Morris Losurdo, Matteo Pedrazzoli, Claudia D'Agostino, Chiara A. Elia, Francesca Massenzio, Elena Lonati, Mario Mauri, Laura Rizzi, Laura Molteni, Elena Bresciani, Erica Dander, Giovanna D'Amico, Alessandra Bulbarelli, Antonio Torsello, Michela Matteoli, Mario Buffelli, Silvia Coco
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Oxford University Press 2020-09-01
Серія:	Stem Cells Translational Medicine
Предмети:	Alzheimer's disease dendritic spines extracellular vesicles inflammation mesenchymal stem cells microglia
Онлайн доступ:	https://doi.org/10.1002/sctm.19-0327
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