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Hyperphosphorylation-induced tau oligomers

In normal adult brain the microtubule associated protein tau contains 2–3 phosphates per mole of the protein and at this level of phosphorylation it is a soluble cytosolic protein. The normal brain tau interacts with tubulin and promotes its assembly into microtubules and stabilizes these fibrils. I...

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Detalles Bibliográficos
Principais autores: Khalid eIqbal, CHENG-XIN eGONG, Fei eLiu
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Neurology
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Acceso en liña:http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00112/full
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