Enhancing portability of trans-ancestral polygenic risk scores through tissue-specific functional genomic data integration.
Portability of trans-ancestral polygenic risk scores is often confounded by differences in linkage disequilibrium and genetic architecture between ancestries. Recent literature has shown that prioritizing GWAS SNPs with functional genomic evidence over strong association signals can improve model po...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science (PLoS)
2024-08-01
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| Σειρά: | PLoS Genetics |
| Διαθέσιμο Online: | https://doi.org/10.1371/journal.pgen.1011356 |
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