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Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Naturally occurring substances are valuable resources for drug development. In this respect, chalcones are known to be antiproliferative agents against prostate cancer cell lines through various mechanisms or targets. Based on the literature and preliminary results, we aimed to study and optimise th...

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Auteurs principaux: Gabriele Möller, Veronika Temml, Antonio Cala Peralta, Océane Gruet, Pascal Richomme, Denis Séraphin, Guillaume Viault, Luisa Kraus, Petra Huber-Cantonati, Elisabeth Schopfhauser, Johanna Pachmayr, Janina Tokarz, Daniela Schuster, Jean-Jacques Helesbeux, Kenneth Allen Dyar
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2022-01-01
Collection:Metabolites
Sujets:
chalcone
aldo-keto reductase
cancer
AKR1C3
17β-hydroxysteroid dehydrogenase
3α-hydroxysteroid dehydrogenase
Accès en ligne:https://www.mdpi.com/2218-1989/12/2/99
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