Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

Abstract Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional analysis of genes linked to PD have revealed that the E3 ligase Parkin and the mitochondrial k...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-01-01
coleção:	Molecular Neurodegeneration
Assuntos:	CISD1 CISD2 Cisd Parkinson’s disease Neurodegeneration Mitophagy
Acesso em linha:	https://doi.org/10.1186/s13024-024-00701-3
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!