Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications

The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When the precursor is cleaved by metalloproteinases, a soluble form (sHB-EGF) is formed that can bind to the EGF receptors, resulting in activati...

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Autores principales:	L. M. Dronko, T. M. Lutsenko, N. V. Korotkevych, I. O. Vovk, D. A. Zhukova, S. I. Romaniuk, A. A. Siromolot, A. J. Labyntsev, D. V. Kolybo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2024-10-01
Colección:	The Ukrainian Biochemical Journal
Materias:	cell proliferation diphtheria toxin egf receptor heparin-binding egf-like growth factor signal transduction wound healing
Acceso en línea:	http://ukrbiochemjournal.org/wp-content/uploads/2024/10/Dronko_96_5.pdf
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