Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

Abstract Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical regulator of muscle mass. The recent...

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Hlavní autoři:	Jeong‐A Lim, Lishu Li, Orian S Shirihai, Kyle M Trudeau, Rosa Puertollano, Nina Raben
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2017-01-01
Edice:	EMBO Molecular Medicine
Témata:	autophagy lysosomal storage disorders mTOR myopathy Pompe disease
On-line přístup:	https://doi.org/10.15252/emmm.201606547
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