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Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis

Highly Pathogenic Avian Influenza Viruses (HPAIVs) arise from low pathogenic precursors following spillover from wild waterfowl into poultry populations. The main virulence determinant of HPAIVs is the presence of a multi-basic cleavage site (MBCS) in the hemagglutinin (HA) glycoprotein. The MBCS al...

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Principais autores: Anja C. M. de Bruin, Mathis Funk, Monique I. Spronken, Alexander P. Gultyaev, Ron A. M. Fouchier, Mathilde Richard
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-07-01
Serier:Viruses
Fag:
Highly Pathogenic Avian Influenza Viruses
Low-Pathogenic Avian Influenza Viruses
multibasic cleavage site
virulence
pathogen evolution
proteolytic cleavage
Online adgang:https://www.mdpi.com/1999-4915/14/7/1566
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