An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins

Abstract The continuous evolution and global spread of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose major challenges for pandemic preparedness. This study evaluates a low-dose inactivated split-virus vaccine derived from H5N1 clade 2.3.4.4b, formulated wit...

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Autori principali:	Eduard Puente-Massaguer, Thales Galdino Andrade, Michael J. Scherm, Kirill Vasilev, Hassanein Abozeid, Alesandra J. Rodriguez, Joshua Yueh, Disha Bhavsar, John D. Campbell, Dong Yu, Richard J. Webby, Yoshihiro Kawaoka, Gabriele Neumann, Julianna Han, Andrew B. Ward, Florian Krammer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-01-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-68457-6
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