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A Novel Hydroxamic Acid-Based Curcumin Derivative as Potent Histone Deacetylase Inhibitor for the Treatment of Glioblastoma

Glioblastoma (GBM) is one of the most common primary and deadliest malignant brain tumor with chemoresistance and poor prognosis. There is a lack of effective chemotherapeutic drug for the treatment of GBM. In this work, we reported the preparation of a histone deacetylase (HDAC) inhibitor, DMC-HA,...

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Autori principali: Hao Wang, Lei Shi, Zhimin Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-11-01
Serie:Frontiers in Oncology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2021.756817/full
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