HHV-6A Drives Epigenetic Reprogramming via an EZH2–SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling

We previously demonstrated that human herpesvirus 6A infects papillary thyroid cancer cells (BCPAP), inducing molecular changes compatible with a tumor-promoting phenotype, including increased expression of R273H mutant TP53 (mutp53), upregulation of c-Myc, and enhanced secretion of IL-6. To investi...

Descripció completa

Dades bibliogràfiques

Autors principals:	Rossella Benedetti, Michele Di Crosta, Alessia Stirparo, George Alexandru Aron, Stefania Mardente, Roberta Santarelli, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-03-01
Col·lecció:	Viruses
Matèries:	HHV-6A EZH2 SIRT1 mutp53 c-Myc IL-6
Accés en línia:	https://www.mdpi.com/1999-4915/18/4/409
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!