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Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

<p>Abstract</p> <p>5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloid leukemia (AML) and other malignancies. 5-AZA-CdR can reactivate tumor...

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Principais autores: Karahoca Metin, Momparler Richard L
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2013-02-01
Serier:Clinical Epigenetics
Fag:
Decitabine
5-aza-2’-deoxycytidine
Epigenetics
AML
MDS
DNA methylation
Pharmacokinetics
Pharmacodynamics
Online adgang:http://www.clinicalepigeneticsjournal.com/content/5/1/3
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