Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells

Background: Hepatic stellate cell (HSC) activation is essential for the development of liver fibrosis. Epigenetic machinery, such as DNA methylation, is largely involved in the regulation of gene expression during HSC activation. Although the pharmacological DNA demethylation of HSC using 5-aza-2′-d...

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主要な著者:	Kiyoshi Asada, Kosuke Kaji, Shinya Sato, Kenichiro Seki, Naotaka Shimozato, Hideto Kawaratani, Hiroaki Takaya, Yasuhiko Sawada, Keisuke Nakanishi, Masanori Furukawa, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Ryuichi Noguchi, Takemi Akahane, Hitoshi Yoshiji
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-06-01
シリーズ:	Biology
主題:	hydralazine 5-aza-2′-deoxycytidine DNA methylation hepatic stellate cell liver fibrosis
オンライン･アクセス:	https://www.mdpi.com/2079-7737/9/6/117
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