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Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity

Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones <b>2a</b>–<b>f</b> and <b>3a</b>–<b>e</b> were designed as candidate antineoplastic agents. These compounds display potent cytotoxicity towards two colon cancers, as well as several oral squamous cell carcinomas. These compounds ar...

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Principais autores: Aruna Chhikara, Praveen K. Roayapalley, Hiroshi Sakagami, Shigeru Amano, Keitaro Satoh, Yoshihiro Uesawa, Umashankar Das, Swagatika Das, Edgar A. Borrego, Cristina D. Guerena, Clare R. Hernandez, Renato J. Aguilera, Jonathan R. Dimmock
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Molecules
Fag:
conjugated unsaturated ketones
cytotoxicity
4-piperidones
selectivity index
apoptosis
reactive oxygen species
Online adgang:https://www.mdpi.com/1420-3049/27/19/6718
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