Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity

Two series of novel unsymmetrical 3,5-bis(benzylidene)-4 piperidones <b>2a</b>–<b>f</b> and <b>3a</b>–<b>e</b> were designed as candidate antineoplastic agents. These compounds display potent cytotoxicity towards two colon cancers, as well as several oral squamous cell carcinomas. These compounds ar...

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Autors principals:	Aruna Chhikara, Praveen K. Roayapalley, Hiroshi Sakagami, Shigeru Amano, Keitaro Satoh, Yoshihiro Uesawa, Umashankar Das, Swagatika Das, Edgar A. Borrego, Cristina D. Guerena, Clare R. Hernandez, Renato J. Aguilera, Jonathan R. Dimmock
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-10-01
Col·lecció:	Molecules
Matèries:	conjugated unsaturated ketones cytotoxicity 4-piperidones selectivity index apoptosis reactive oxygen species
Accés en línia:	https://www.mdpi.com/1420-3049/27/19/6718
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