Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

Abstract Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targeted FGF/FGFR signaling for cancer therapy and several FGFR inhibitors...

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Bibliografische gegevens

Hoofdauteurs:	Ruiwen Ruan, Li Li, Xuan Li, Chunye Huang, Zhanmin Zhang, Hongguang Zhong, Shaocheng Zeng, Qianqian Shi, Yang Xia, Qinru Zeng, Qin Wen, Jingyi Chen, Xiaofeng Dai, Jianping Xiong, Xiaojun Xiang, Wan Lei, Jun Deng
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2023-03-01
Reeks:	Molecular Cancer
Onderwerpen:	Fibroblast growth factor receptor Immune checkpoint blockade Tumor microenvironment Immunotherapy
Online toegang:	https://doi.org/10.1186/s12943-023-01761-7
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