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Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

Overexpression of human epidermal growth factor receptor type 3 (HER3) is associated with tumour cell resistance to HER-targeted therapies. Monoclonal antibodies (mAbs) targeting HER3 are currently being investigated for treatment of various types of cancers. Cumulative evidence suggests that affibo...

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Principais autores: Mohamed Altai, Charles Dahlsson Leitao, Sara S. Rinne, Anzhelika Vorobyeva, Christina Atterby, Stefan Ståhl, Vladimir Tolmachev, John Löfblom, Anna Orlova
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-10-01
coleção:Cells
Assuntos:
HER3
affibody
molecular design
therapy
Acesso em linha:http://www.mdpi.com/2073-4409/7/10/164
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