Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Signal-regulatory protein α (SIRPα) expressed by myeloid cells is of particular interest for therapeutic strategies targeting the interaction between SIRPα and the “don’t eat me” ligand CD47 and as a marker to monitor macrophage infiltration into tumor lesions. To address both approaches, we develop...

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Dettagli Bibliografici

Autori principali:	Teresa R. Wagner, Simone Blaess, Inga B. Leske, Desiree I. Frecot, Marius Gramlich, Bjoern Traenkle, Philipp D. Kaiser, Dominik Seyfried, Sandra Maier, Amélie Rezza, Fabiane Sônego, Kader Thiam, Stefania Pezzana, Anne Zeck, Cécile Gouttefangeas, Armin M. Scholz, Stefan Nueske, Andreas Maurer, Manfred Kneilling, Bernd J. Pichler, Dominik Sonanini, Ulrich Rothbauer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-12-01
Serie:	Frontiers in Immunology
Soggetti:	nanobodies (Nbs) SIRPalpha myeloid cells PET imaging tracer immune checkpoint inhibitor (ICI) theranostics
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264179/full
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