Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine
The multiple transmembrane protein Niemann-Pick C1 like1 (NPC1L1) is essential for intestinal cholesterol absorption. Ezetimibe binds to NPC1L1 and is a clinically used cholesterol absorption inhibitor. Recent studies in cultured cells have shown that NPC1L1 mediates cholesterol uptake through vesic...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2012-10-01
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| Serija: | Journal of Lipid Research |
| Teme: | |
| Online dostop: | http://www.sciencedirect.com/science/article/pii/S0022227520431864 |
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