Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Abstract Introduction Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal breast cancer, and approximately 20% of screen-detected tumours are pure DCIS. Most risk factors for breast cancer have similar associations with DCIS and IDC; however, there is limited data on the p...

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Главные авторы:	Christos Petridis, Iteeka Arora, Vandna Shah, Anargyros Megalios, Charlotte Moss, Anca Mera, Angela Clifford, Cheryl Gillett, Sarah E. Pinder, Ian Tomlinson, Rebecca Roylance, Michael A. Simpson, Elinor J. Sawyer
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2019-05-01
Серии:	Breast Cancer Research
Предметы:	Germline variants BRCA2 CHEK2 PALB2 BRCA1 TP53
Online-ссылка:	http://link.springer.com/article/10.1186/s13058-019-1143-y
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