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Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers

PALB2 is an important BRCAx candidate for familial breast cancers (FBC). PALB2 pathogenic variants (PVs) may not to conform to “two hit” paradigm. However, a recent study demonstrates that in the majority PALB2 germline mutant breast cancers, the loss of heterozygosity (LOH) and somatic point mutati...

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Principais autores: Zhe-Yu Hu, Liping Liu, Ning Xie, Jun Lu, Zhentian Liu, Yu Tang, Yikai Wang, Jianbo Yang, Quchang Ouyang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-08-01
Serier:Frontiers in Genetics
Fag:
germline PALB2 mutation
hereditary breast cancer
loss of heterozygosity
somatic mutations
mutational signature
Online adgang:https://www.frontiersin.org/article/10.3389/fgene.2020.00829/full
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