Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer

Abstract Radiotherapy resistance remains a major clinical challenge, largely driven by tumors’ ability to dynamically adapt through complex molecular networks. Critically, the ubiquitin system has emerged as a critical regulator of this resistance. This review examines how the ubiquitin system orche...

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Autors principals:	Fu-Ying Zhao, Li-Ye Shi, Lu-Jiao Yu, Si-Qi Wang, Chu-Yao Sun, Na Zhang, Hua-Qin Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Molecular Cancer
Matèries:	Ubiquitination modification Radiotherapy resistance DNA damage repair Deubiquitinases (DUBs) Ferroptosis Metabolic reprogramming
Accés en línia:	https://doi.org/10.1186/s12943-025-02433-4
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