Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer

Abstract Radiotherapy resistance remains a major clinical challenge, largely driven by tumors’ ability to dynamically adapt through complex molecular networks. Critically, the ubiquitin system has emerged as a critical regulator of this resistance. This review examines how the ubiquitin system orche...

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Principais autores:	Fu-Ying Zhao, Li-Ye Shi, Lu-Jiao Yu, Si-Qi Wang, Chu-Yao Sun, Na Zhang, Hua-Qin Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-10-01
Series:	Molecular Cancer
Assuntos:	Ubiquitination modification Radiotherapy resistance DNA damage repair Deubiquitinases (DUBs) Ferroptosis Metabolic reprogramming
Acceso en liña:	https://doi.org/10.1186/s12943-025-02433-4
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