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CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3

The vertebrate visual cycle hinges on enzymatically converting all-trans-retinol (at-ROL) into 11-cis-retinal (11c-RAL), the chromophore that binds to opsins in photoreceptors, forming light-responsive pigments. When struck by a photon, these pigments activate the phototransduction pathway and initi...

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Principais autores: Vineeta Kaushik, Luca Gessa, Nelam Kumar, Matyáš Pinkas, Mariusz Czarnocki-Cieciura, Krzysztof Palczewski, Jiří Nováček, Humberto Fernandes
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2025-01-01
Serier:Open Biology
Fag:
RBP3
cryoEM structure
SAXS
conformational changes
molecular docking
Online adgang:https://royalsocietypublishing.org/doi/10.1098/rsob.240180
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