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LRP1 facilitates Jamestown Canyon virus infection of neurons

ABSTRACT Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus that causes viral neuroinvasive disease in North America. JCV neuropathogenesis is understudied, and no pro-viral host factors for cellular infection have been identified. Here, we assessed the role of low-density lipoprotein recept...

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Autori principali: Zachary D. Frey, David A. Price, Kaleigh A. Connors, Rachael E. Rush, Griffin Brown, Cade E. Sterling, Farheen Fatma, Safder S. Ganaie, Xiaoxia Cui, Zachary P. Wills, Gaya K. Amarasinghe, Daisy W. Leung, Amy L. Hartman
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2025-12-01
Serie:Journal of Virology
Soggetti:
Jamestown Canyon virus
primary rat neurons
LRP1
CD91
bunyavirus
host factor
Accesso online:https://journals.asm.org/doi/10.1128/jvi.01841-25
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