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Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs

Chronic infection with hepatitis B virus (HBV) remains a problem of global significance and improving available treatment is important to prevent life-threatening complications arising in persistently infected individuals. HBV is susceptible to silencing by exogenous artificial intermediates of the...

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Principais autores: Mohube Betty Maepa, Abdullah Ely, Wayne Grayson, Patrick Arbuthnot
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-06-01
coleção:Molecular Therapy: Nucleic Acids
Assuntos:
HBV
RNAi
Pol II
scAAV8
transgenic mice
interferon response
proinflammatory cytokines
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253117301579
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