Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs

Chronic infection with hepatitis B virus (HBV) remains a problem of global significance and improving available treatment is important to prevent life-threatening complications arising in persistently infected individuals. HBV is susceptible to silencing by exogenous artificial intermediates of the...

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Autors principals:	Mohube Betty Maepa, Abdullah Ely, Wayne Grayson, Patrick Arbuthnot
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-06-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	HBV RNAi Pol II scAAV8 transgenic mice interferon response proinflammatory cytokines
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253117301579
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