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The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

Ferroptosis is an iron-dependent cell death caused by impaired glutathione metabolism, lipid peroxidation and mitochondrial failure. Emerging evidences report a role for ferroptosis in Friedreich's Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial pro...

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Principais autores: Piergiorgio La Rosa, Sara Petrillo, Riccardo Turchi, Francesco Berardinelli, Tommaso Schirinzi, Gessica Vasco, Daniele Lettieri-Barbato, Maria Teresa Fiorenza, Enrico S. Bertini, Katia Aquilano, Fiorella Piemonte
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-01-01
Serier:Redox Biology
Fag:
Friedreich ataxia
Nrf2
Ferroptosis
Redox imbalance
Sulforaphane
EPI-743
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231720309964
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