HIVIL: A human in vitro inflammatory liver model recapitulates immune-associated drug effects with high predictivity

DILI (Drug Induced Liver Injury) is one of leading cause of failure in drug development due to adverse reaction outcomes and health hazards. Besides, understanding DILI is challenging due to lack of relevant in vitro models] that recapitulate human in vivo physiological responses. Current in vitro m...

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Hlavní autoři:	Xiaozhong Huang, Yun Ting Soong, Jiahao Wang, Claire Jia Yi Ng, Kartik Mitra, Farah Tasnim, Hanry Yu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-01-01
Edice:	NAM Journal
Témata:	Drug-induced liver injury hiPSC-derived Kupffer cells In vitro liver model Cytokines
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S3050620425000272
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