ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains

Abstract The cellular response to lysosomal damage involves fine-tuned mechanisms of membrane repair, lysosome regeneration and lysophagy, but how these different processes are coordinated is unclear. Here we show in human cells that the deubiquitinating enzyme ATXN3 helps restore integrity of the l...

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Principais autores:	Maike Reinders, Bojana Kravic, Pinki Gahlot, Sandra Koska, Johannes van den Boom, Nina Schulze, Sophie Levantovsky, Stefan Kleine, Markus Kaiser, Yogesh Kulathu, Christian Behrends, Hemmo Meyer
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer Nature 2025-07-01
Series:	The EMBO Journal
Assuntos:	Lysosome Stress Response Ubiquitin Membrane Autophagy
Acceso en liña:	https://doi.org/10.1038/s44318-025-00517-x
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