ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
Abstract The cellular response to lysosomal damage involves fine-tuned mechanisms of membrane repair, lysosome regeneration and lysophagy, but how these different processes are coordinated is unclear. Here we show in human cells that the deubiquitinating enzyme ATXN3 helps restore integrity of the l...
保存先:
| 主要な著者: | , , , , , , , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Nature
2025-07-01
|
| シリーズ: | The EMBO Journal |
| 主題: | |
| オンライン・アクセス: | https://doi.org/10.1038/s44318-025-00517-x |
| タグ: |
タグなし, このレコードへの初めてのタグを付けませんか!
|
