Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain

Abstract Major histocompatibility class II (MHC II) is critical for adaptive immunity. MHC II intracellular trafficking and degradation is regulated by ubiquitination. Poly-ubiquitination (Ub) of MHC II directs it away from the plasma membrane and is a critical determinant of MHC II turnover. The MH...

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Ngā kaituhi matua:	Haiyin Liu, Lauren Francis, Laura F. Dagley, Simon A. Cobbold, Andrew I. Webb, David Komander, Jose A. Villadangos, Justine D. Mintern
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2025-11-01
Rangatū:	Scientific Reports
Urunga tuihono:	https://doi.org/10.1038/s41598-025-25817-4
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!