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How soluble misfolded proteins bypass chaperones at the molecular level

Abstract Subpopulations of soluble, misfolded proteins can bypass chaperones within cells. The extent of this phenomenon and how it happens at the molecular level are unknown. Through a meta-analysis of the experimental literature we find that in all quantitative protein refolding studies there is a...

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Hlavní autoři: Ritaban Halder, Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu, Mai Suan Li, Justin Pritchard, Edward P. O’Brien
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2023-06-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-023-38962-z
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