Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice

Abstract Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent accumulation of complement components on the renal glomeruli. This leads to condi...

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Auteurs principaux:	Federica Casiraghi, Pamela Yossenaidy Rodriguez Ordonez, Nadia Azzollini, Marta Todeschini, Daniela Rottoli, Roberta Donadelli, Roberto Gramignoli, Ariela Benigni, Marina Noris, Giuseppe Remuzzi
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2021-06-01
Collection:	Stem Cell Research & Therapy
Sujets:	Human amnion epithelial cells Complement factor H Complement alternative pathway Renal glomeruli Complement deposition
Accès en ligne:	https://doi.org/10.1186/s13287-021-02386-7
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