Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed...

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Detalhes bibliográficos

Principais autores:	Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2022-01-01
coleção:	eLife
Assuntos:	ligand-gated ion channel docosahexaenoic acid polyunsaturated fatty acid photoaffinity labeling mass spectrometry coarse-grained molecular dynamics simulations
Acesso em linha:	https://elifesciences.org/articles/74306
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