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Integrated spatial multi-omics delineates fatty acid degradation fuels malignant evolution at the tumour periphery in cervical squamous cell carcinomaResearch in context

Summary: Background: Cervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood. Methods: In this study, we performed an integrated spatial transcriptomic and metabo...

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Principais autores: Shitong Lin, Zhihui Luo, Yuting Li, Bai Hu, Minghan Qu, Binghan Liu, Canhui Cao, Ting Peng, Miaochun Xu, Yashi Xu, Xiaojie Liu, Xiaoli Wang, Li Li, Wencheng Ding, Zhenyu Xu, Ruizhi Li, Jingwei Zhao, Jingmin Zhang, Lingfang Wang, Fang Ren, Chaolong Wang, Peng Wu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:EBioMedicine
Fag:
Spatial transcriptomics
Spatial metabolomics
Fatty acid degradation
EMT
CSCC
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396426001386
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