Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction

BackgroundHeart failure with reduced ejection fraction (HFrEF) remains a significant public health issue, with the disease advancing despite neurohormonal antagonism. Energetic dysfunction is a likely contributor to residual disease progression, and we have previously reported a strong association o...

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Κύριοι συγγραφείς:	Vandana Revathi Venkateswaran, Ruicong She, Hongsheng Gui, Jasmine A. Luzum, Timothy D. Bryson, Zack E. Malouf, L. Keoki Williams, Hani N. Sabbah, Stephen J. Gardell, David E. Lanfear
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2024-07-01
Σειρά:	Frontiers in Cardiovascular Medicine
Θέματα:	plasma metabolites heart failure GWAS QTL mediation analysis
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1409340/full
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