Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction

BackgroundHeart failure with reduced ejection fraction (HFrEF) remains a significant public health issue, with the disease advancing despite neurohormonal antagonism. Energetic dysfunction is a likely contributor to residual disease progression, and we have previously reported a strong association o...

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Autori principali:	Vandana Revathi Venkateswaran, Ruicong She, Hongsheng Gui, Jasmine A. Luzum, Timothy D. Bryson, Zack E. Malouf, L. Keoki Williams, Hani N. Sabbah, Stephen J. Gardell, David E. Lanfear
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-07-01
Serie:	Frontiers in Cardiovascular Medicine
Soggetti:	plasma metabolites heart failure GWAS QTL mediation analysis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1409340/full
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